We had the exact same issue with the AGS JSAPI Map where map click was not firing. This was fixed by deleting the affected user's Chrome profile and letting it recreate the profile.
Uninstalling and Reinstalling preserves the profile by default.
But don't forget to take a backup of Your bookmards settings etc. before deleting the profile.
This workaround fixed the issue at almost all of our client's who had this issue.
So, You will have to delete and recreate the user profile manually.