Issue: This is related to the following KB: “Restore RegisterAddin.exe file association for ArcGS Pro SDK Addins and Configurations”. After installing either of the ArcGIS Pro 3.4.1 or 3.3.3 patches, developers using the ArcGIS Pro SDK NuGet package may notice that their addins are no longer being registered as part of the compilation process in Visual Studio. For example, developers may notice that their breakpoints are not being hit when debugging their addin in Visual Studio.
Developers using assembly references in their addins, instead of the Nuget, will not experience this issue.
Cause:
The patches move the location of RegisterAddin.exe from ProgramData to the ArcGIS Pro bin folder. This is described within the KB. As a result, the Nuget no longer invokes RegisterAddin.exe after compile to (re) register the addin.
Solution:
Update the ArcGIS Pro SDK Nuget to the latest version relevant to your release of Pro. If you are using the ArcGIS Pro 3.3.3 patch, please update your Nuget version to 3.3.3. If you are using the ArcGIS Pro 3.4.1 patch, please update your Nuget version to 3.4.1.

Steps to Update ArcGIS Pro SDK NuGet Packages:
1. Open Visual Studio.
2. Load the affected ArcGIS Pro add-in or configuration project.
3. Check the current NuGet package version:
o Go to Tools > NuGet Package Manager > Manage NuGet Packages for Solution.
o Select the Installed tab and locate the Esri.ArcGISPro.Extensions30 packages.
4. Update the NuGet packages:
o If you have ArcGIS Pro 3.4 installed, update the Esri.ArcGISPro.Extensions30 package to 3.4.1.55405
o If you have ArcGIS Pro 3.3 installed, update the Esri.ArcGISPro.Extensions30 package to 3.3.3.52636
o Ensure all installed ArcGIS Pro SDK packages are updated.
5. Clean and rebuild the project:
o Navigate to Build > Clean Solution.
o Then, navigate to Build > Rebuild Solution.
6. Attempt to debug the project again. For further assistance, refer to the ArcGIS Pro SDK documentation or contact Esri Technical Support.