Thanks for you suggestion regarding "calculate Statistics". Actually, I do Calculate Statistics, on the Raster Mosaic Dataset after I've created it and then added my rasters to it. I had read on other threads that the Calculate Statistics is very necessary.So, I think I'm in the same position as you are -- having to manually change the symbolization after the dataset is created and data added. Maybe this would be a good item to put on ESRI's "wish list"?In reading your post again, you mention that you can't programmatically Calculate Statistics; I'm able to do it with the following code: ##Calculate Statistics.
arcpy.AddMessage("Calculating Statistics for " + ras + ".")
arcpy.CalculateStatistics_management(ras, "1", "1", "#", "OVERWRITE")