“OK” button for Application Theme grayed out

[TimothyBowser1]

I am running ArcGIS Pro 2.7.2. I am trying to change the Application Theme to “Dark”. When I go to the Application Theme setting in Options, the “OK” button is grayed out and I can not commit the change.

I have uninstalled and reinstalled ArcGIS Pro twice and I still can not change the setting. My high contrast setting is off. At this point, I believe it’s a setting on my laptop but I am not sure what setting it can be.

Any suggestions?

[DanPatterson]

Visual modes of operation—ArcGIS Pro | Documentation

is high contrast mode on?  if so turn it off

[TimothyBowser1]

My high contrast mode is off.

[JayantaPoddar]

Are you able to make any other changes in the settings?

Have you tried this?

Close all ArcGIS Pro sessions. Run ArcGIS Pro as administrator.

[TimothyBowser1]

I am not able to make any changes in the options window because the "OK"
button is grayed out as soon as I open it.

I tryed running ArcGIS Pro as an Administrator but, it did not solve the
issue.

[TimothyBowser1]

I am not able to make any changes in the options window because the "OK" button is grayed out as soon as I open it.

I tried running ArcGIS Pro as an Administrator but, it did not solve the issue. 

[TimothyBowser1 · Accepted solution]

The issue was with the custom project location. (General -> Create Projects -> Project location) The custom location directory was invalid due to the folder location being deleted. Once updated with a valid location, the "OK" button was available and all settings were able to be saved.

[Carrie]

For me, both my default Geodatabase and Toolbox in the Create Projects section had lost their connections, so it wouldn't activate the OK button when until I reconnected them. I also noticed a slight red line under the the word General in the left pane of the Options navigation pane.