Multiple Layouts with Different Labels

[JohnBornsworth]

Hello! I'm an environmental consultant who uses ArcGIS Pro on the side - my knowledge is limited to what I do repeatedly. I have a new task where I want to make a few different layouts presenting data on my map differently. I added a new layout from a template I have, added a map wire and modified the map within my Layout's Content Pane. Then I went back to my Map tab, and all the changes I made within the Layout Tab are reflected in the Map. The layout is just different labels and different layers shown. How can I make a layout that doesn't change it's label/layers/symbols when I change my map or vice versa?  

JHB 

[Robert_LeClair]

Currently there is no way to do this other than creating multiple copies of the Map View for different layouts.  There is an enhancement request - ENH000151832 - "Add ability to freeze a map frame and map-based cartographic elements when there are several map frames accessing data from one map." to have this type of workflow.