Hello. I've had this same issue for a number of years. I recently have switched to ArcGIS Pro from 10.3 and have still having a similar issue.
My cursor often becomes stuck on the pan (10.3) or the rotate (Pro) tool. No matter what I try, I'm not able to use any other cursor functions. Sometimes a full computer restart fixes this issue, but not always. No key command or escape key command fixes this issue.
Any suggestion? Thanks.