If it happens outside of a project, it could still be a data connection. Do you have anything in your Favorites list in your Catalog?
Between your "slow machine" and the lower-spec laptop, are there differences with where the program is installed, or any other user settings?
My desktop machine used to be very slow with certain aspects of Pro because it was trying to save / backup items to a network location rather than on the local machine. Going through all my application settings and making sure everything was local significantly improved things.
- Josh Carlson
Kendall County GIS