Because of a server policy, the installation directory for ArcGIS Data Store was set to
So far, this hasn't caused any problems (we only use a relational tile store), but we are noticing an issue when upgrading from 10.5.1 to 10.6.1 during the final stage of Complete Upgrade. It might be related to this technical article regarding spaces in the filename.
Is there a technical article on how to change the installation directory of DataStore? Its high-availability, so my one thought is just to un-pair them, reinstall one to a directory with no spaces, rejoin, then do the same with the other data store.
I was able to find this article on changing the default folder location can be changed using ArcGIS Data Store command utilities from the Windows Command Prompt
How To: Change the ArcGIS Data Store default folder location to a different storage drive
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Let me know if you have questions.