Theoretically not, but I've had 1 other customer had issue with loading stuff ( workspaces, projects ) from somewhere in the network. the poor girl had to create new workspaces quite often.
We've done some tests for this some time ago, where it worked. but as you know, there may be any number of possible issues else, which influence such endeavors. Plus, it's almost impossible to reproduce such issues if you don't have the exact same setup.
Good luck - let me know how it goes.
Anyway - I'd recommend to work on one 'beastly machine' anyway, with fast harddrive and graphics card.. avoiding any network latency, especially when working with big datasets.