QT announced support for PySide2
Qt for Python 5.12 Released - Qt Blog
PySide2 · PyPI
ESRI has its Runtime for QT (100.4):
ArcGIS Runtime SDK for Qt (latest) | ArcGIS for Developers
How hard would it be to write python apps in QT creator that pop a map using the ArcGIS Runtime for QT where the app UI is defined in QML?