Accessing file-gdb over network not advisable, why?

Discussion created by maphew on Jun 25, 2014
Latest reply on Jun 26, 2014 by vangelo-esristaff
In another thread the formidable Vince Angelo was seen saying "It's best practice to not access FGBDs over a network link". Would someone in the know please expand on that? What makes it not best practice?

I'm most interested in read-by-many users and write-by-one (or few) scenario but please feel free to go beyond that. Thanks.