Multi-variate interpolation in ArcGIS Pro

[MichaelSchoelen]

I'm trying to create a map similar to the one below--essentially an interpolated map, but using multiple categorical variables. Has anyone seen an application of interpolation that can do this in ArcGIS? 

I attempted to do it with just some hotspot symbology, and it didn't quite blend right. Plus, I would rather have a singular dataset that can be masked and analyzed. 

Probably a good question for John Nelson‌