if windows[0] == "6":     trans_dir = os.getenv("USERPROFILE") +os.sep+ r"AppData\Roaming\ESRI\Desktop10.0\ArcToolbox\CustomTransformations" elif windows[0] == "5":     trans_dir = os.getenv("USERPROFILE") +os.sep+ r"Application Data\ESRI\ArcToolbox\CustomTransformations"Solved! Go to Solution.
import arcpy
import os
def ArcGISProfile(profilePath=None):
    """ArcGIS Windows user profile path"""
    APPDATA = arcpy.GetSystemEnvironment("APPDATA")
    if arcpy.GetInstallInfo("DESKTOP")['Version'].find("10") == -1:
       path = os.path.join(APPDATA,"ESRI")
    else:
       path = os.path.join(APPDATA,"ESRI/Desktop10.0/")
    return os.path.realpath(os.path.join(path,profilePath))
print ArcGISProfile("ArcToolbox\CustomTransformations")C:\Documents and Settings\cprice\Application Data\ESRI\Desktop10.0\ArcToolbox\CustomTransformations
