I don't see why that wouldn't work - it is just like clipping with any other polygon. Analysis, Analysis Tools, Extract, Clip. Clip (Analysis)—ArcGIS Pro | Documentation What kind of problem are you running into that prompts this question?
Thanks, Jay. I don't have Network Analyst so I can't create drive-times in Pro. I tried it Online where I can create drive-time polygons and at least so far that didn't work either. Could be "operator error" so I'll keep trying.