In some cases, users may still want to store LAS datasets in SDE, even though this approach is not common, especially, in research projects.
For example, after importing from LAS files, the low-level security of LAS datasets can still be managed via SDE, just like Mosaic Datasets, even though not common.
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On LAS datasets imported from LAS files, there are some disadvantages. For example, ArcGIS couldn't do any helps diectly for LAS data files. In other word, the high quality of LAS data files are required, before loading into LAS datasets.
Refer to the blog at Noise Removal and Manual Classification in LAS Cloud