this configuration does not depends on the SDE or SQL Server only. The network infrastructure must support transferring large packets also at the intermediate network devices (Switches, routers, Firewalls. for example if the network device support packets size 1024 B (which is the default) large packets will be divided at the network level hence transfer the performance issue to the network and make it candidate for packet loss. so take care to test the packet size configuration first on your network.