I have a geodatabase that becomes locked when users forget to close ArcMap at night. When the automated nightly data update from our server occurs, the locks cause the geodatabase to become corrupted and inaccessible by other users. Remotely closing the geodatabase seems like a possible solution. Have you noticed any users having problems running Arc after you use psfile.exe to close the geodatabase?
We have not seen any trouble with this. No corruption. And this GDB is used to publish layers to ArcGIS Server. It has worked flawlessly since implemented.
Just noticed you asked if there were any users who had issues. There are no MXD's pointed to this data other than those used for creating the map services. Therefore, the locks are created by ArcGIS Server. In our case, the server refreshes bad connections every 30 min so we don't have a problem. I don't know what it would look like to a user if they had a map open and you ran this.