I can't give you a definitive answer, but in my experience scripting does not work in ArcReader
You could use ArcMap and just remove toolbars and maybe even the table of contents so it looks simple. This is an expensive way to go.
You could create five different projects and just train the users on which project to open.
The cutting edge solution: ArcGIS server 10.2 is supposed to allow offline mapping. Talk to ESRI about this, it sounds like this feature is right up your alley.