I supplied a standalone VB.NET program to my department that was developed and ran fine on Desktop R9.3. Recently everyone migrated to R10 and I migrated my development environment to R10 and Visual Studio 2010. I followed the ESRI migration recommendations, recompiling and making the necessary changes. The routine tested fine on my machine (Windows 7) and on several other users' R10 Windows 7 machines. However, there is one machine, a Dell running Windows 7 and R10 on which it will not execute correctly. Upon execution the splash screen displays correctly then I get a message from the operating system telling me there was a problem and it's checking for a solution (course it can't find one). I've checked all the usual suspects: dotnet framework, target environment, etc. Anyone run into a problem like this or know of anything other than the suggested ESRI migration changes that could be causing the problem?