I have forever been plagued with the "ArcGIS for Desktop has encountered a serious application error." Without fail, I get this error message every day, even when I'm not using any ESRI products. I can go weeks without using ArcGIS and I will still get this error every day.
The problem has been going on for at least 6 months, but it didn't really bother me until recently. Now, it's happening every hour. I am using 10.5.
Any thoughts on what I can do to stop the persistent application error message?
Call technical support. It could be one of many things.
I assume you have done a complete uninstall and reinstall of all esri products.
Also, do the crashes happen with new projects or only existing ones?
They will require information on what you are using, your computer specs and myriad of other bits of information.