Changing symbology of a SDE point feature class in Pro 2.2:
Note how long it takes. Looking at wireshark logs while this is occurring, an incredible amount of traffic is going back and forth to SDE. Why? Because in Arc Map, I can change the symbology 5 times in the same amount of time it takes to change symbology in Pro. And guess how much back and forth is occurring with SDE when I do this in Arc....not much...
Performance gets even worse when you turn off caching for a map layer, which was the solution to BUG-000113527 ArcGIS Pro Attribute pane fails to dynamically update data for values calculated through SQL for published feature services.
The result of the bug that I logged on this in 2.1 is "Implemented in 2.2", so I'm hopeful that others in the community are experiencing this same specific issue: "Changing symbology in Pro takes 2-10 times longer in Pro than the same exact SDE data source does in Arc" and can get some attention on this issue that, judging from the other posts in this thread, probably affects a very large number of enterprise customers. I plan to reopen the case, but expect a "cannot reproduce" outcome......