The data interoperability extension now supports reading mbtiles, which you can now use to write to FGDB raster, and then create a tile package from that.
The TPKX is now also built on sqlite and the tile structure closely resembles MBTILES, so in theory you could convert pythonically.
Thanks a lot for your answer. But I'm a pretty newbie with ArcGIS Pro. Could you tell me how to manipulate step by step?
For example , is "data interoperability extension" a tool or just a term. And how to "reading mbtiles" in ArcGIS Pro? And how to "write to FGDB raster"?