If the user activates a map pane in a layout and does editing, they can close that activation without realizing that there are unsaved edits. Once returning to the layout there is no way to save edits.
Case use: I have a layout with a zoning exhibit map that shows a single parcel. I have to activate the map pane and draw a notification boundary around the subject tract, then buffer that boundary. When I finish, I close the activation to return to the layout and fix up the printable map. However, if I forgot to save the edits I get no warning or any way to save those edits. I usually find out when I close the project and I get prompted to save edits ... or sometimes I run a geoprocessing tool and I get a warning that there are unsaved edits.
It would be better if I was prompted to save edits when I click Close Activation.