I have used and found many ways to disable PopUps, lately in Pro, my usual workflow prompting this is during editing sessions. Other workflows where this would be useful are out there. I offer no guarantee this hasn't been asked for already.
A useful time saver would be to Disable PopUps on the entire "Map", possibly within Properties or within the Right-Click context upon "Map" tab above TOC pane.
Each layer can have its PopUps Enabled or Disabled, so with multi-clicks it can be accomplished.
I'm inquiring about a more global Map-tab-wide override to disable.