Hello @KatieDarcy,
There might be various reasons why this happens.
Sometimes when we select features on the map, especially using Select by point or Select by line, similar cases happen. Since a point or a line does not have any width, if you zoom to a certain extent, you might find the point is way off where you clicked. That's where buffer distance comes in handy. In some cases, we introduce a certain buffer so that the users could avoid the above issues.
Another possible reason could be, there might be some layer or widget container (which is transparent) overlapping the map area, causing it not accessible.
It might be more clear if you could share the app for trouble-shooting.
Hope it helps,
Tonghui