This issue still exists in 10.5 where it presents, in my case, as "ERROR 1369: Failed to create the service" in ArcMap.
The server log shows "Failed to create the service.: Invalid service definition. Cannot have "mixed" data stores with a feature service"
Removing images from the layout window does resolve the problem. The problem only occurs when "Feature Access" for the service is ticked as one of the Capabilities.