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Hi Robert,
If I may, I would like to share my similar experience with Firefox. I did not have any issue with Chrome and IE but I had same error on my ArcGIS Viewer for Flex apps. ( Silverlight is okay).
After several solutions I tried, I found out that simply adding an entry in the Connection Settings - > No Proxy for: in my case my local ArcGIS Servers ( without the http://) , the Flex Web works. This is not required for Chrome and IE.
Reginaldo,
Thanks for the info. I will try and remember this when helping others.