FYI: just reproduced the same issue in beta 2. Here is what I did. I create Feature Layer, added a polygon layer and a topology rule. I then created an MPK that pointed to external data (ie. the FGDB). I can not add the MPK as a featire layer to a map in the RunTime. At startup, I get a 500, failed to create feature service. If I remove the Topology rule, it works fine.