Asking for a friend....
Dan Patterson (new picture Dan, that is...)
Joe... I didn't have any issues with the 2.6.1 upgrade. It didn't affect anything really important for python at all.
I think it upgraded python to 3.6.10 (I upgraded to 3.6.12 after, I think), which is just security fixes.
I also upgraded Spyder (4.1.5), numpy (1.19.1) and IPython without issues.
The changelog is here
Release notes for ArcGIS Pro 2.6—ArcGIS Pro | Documentation
But if things go bad.
conda list --revisionsconda install --revision N # N is the number of the good times
PS, it is a good idea to do a conda list in your base and your clone to make sure that the versions of any important packages are on the same verison
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