After I installed ENVI Python tools, my default toolboxes no longer load in ArcPro 2.2.0. Anyone else? See attached.
There have been some issues around pyt toolboxes (especially ones with spaces in them).
You could search on GeoNet over the last 30 days if you want to see if there are similar circumstances, but Pro 2.2.1 is supposed to be out by the end of the month.