In addition to "Script" tools, you'll hurt the Calculate Field tool when using Python expressions, as well as any layer properties which use Python. For example you can define label expressions with the Python parser.
Yeah, both of these examples make use of VBScript as the default parser, but removing Python would break that functionality should someone choose it.
My vote is with the masses above : dont remove it. And if you do, make sure thats the very first thing you tell tech support if you call in looking for help on anything. It would be a shame to spend a week on something only to find out that it was related to the Python removal.