As an ex graphic designer myself, I think what I would do in this case is have a page size of your entire unfolded brochure. Use guides, which can be pulled out from the page rulers, to lay out the two sides of the brochure. On the front side, you can have the text boxes, one of which will include the dynamic text for the label address. On the back side will be your data frame which will include the parcel shapefile used to drive the pages, and any other layers you need. You can also specify a page title field, perhaps client name, which can be used to name the exported pages.