Create GUI usuing Python to edit Geodatabase

[GIS_GettingItSolved]

I'm new here and new to working with Python.  That said, I'm trying to create a GUI that includes dropdown menus that the user can use to edit a feature dataset.  I've been working with tkinter to create a GUI with the dropdown options but I'm running into a wall when I try to connect my GUI to my file geodatabase (fgdb).

My question is:  "Is it possible to create a GUI with dropdown menues' that can update a file geodatabase?

Thanks for any input/suggestions/comments!

[GIS_GettingItSolved]

Hi StaticK.  Thank you for the comment!  That's an encouraging reply to see that this is possible but intimidating when considering your comments about the unstableness along with earlier comments by Blake and Hayden.