@MK13 there is not a way to activate a map frame from arcpy.mp and we don't have plans to provide that capability but I would like to hear more about your scenario. We have a few exceptions (e.g., opening and closing views) but try to provide functions that can work with scripts in the application and stand alone scripts outside the application. Activating a map frame would only work in the application. The .NET SDK provides finer grained capabilities to perform operations like this and its main focus with Add-ins is to work within the contest of the application.
Jeff - Layout and arcpy.mp teams
