Great pop-ups for a layer aren't limited to displaying information about that layer alone. In Arcade, geometric relationships are built right into the language. You can use it to create pop-ups that include information about spatially related layers too. This video was recording using ArcGIS Pro 2.9 in January 2022.
For further ArcGIS training, explore Esri Academy's course catalog: https://bit.ly/3oqlqsO.