The whole reason for my original question was because our IT department installed Sophos and it corrupted our Portal. We had thousands of orphaned SOC processes that would never end and would run the machine out of resources. It also caused issues during upgrades that absolutely rendered the Portal inaccessible. We did have IT implement the white list and still had tons of issues that broke ArcGIS Enterprise. So I cannot get on board with Sophos and ArcGIS Enterprise compatibility claims.
We made IT uninstall Sophos and we were able to restore our Portal and start using it again without issues. Now our IT department now wants to force CrowdStrike on us. We are already running it on our workstations and (again, white list exceptions are already in place) we see nothing but issues. Projects locking up and crashing constantly. Simple attribute edits that take minutes to commit. With the issues we have with Pro I am very hesitant to have it installed on our ArcGIS Enterprise servers.
I should point out that there are several typos in the white list and we had to navigate to every single folder to get the actual path (not just blindly copying and pasting the bad paths with typos into the exceptions.)
I am starting to believe that ESRI just doesn't care about their customers as their software is getting progressively worse over time (not better as one would expect from a company with such a large market). Pro (the most user unfriendly software ever developed) and ArcGIS Enterprise are so bug ridden now that it makes me want to retire early.
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