Thanks for the response and link Larry.
I'm not sure that it is just an issue of these GP tools not working on MrSID though, as I've been able to perform Color Balancing on a test Mosaic of MrSID.
Unlike the production mosaic I'm working on, though, I created the test mosaic from scratch and activated the 'Calculate Statistics' option in the Add Rasters to Mosaic Tool' (rather than using the Calculate Stistics Tool or Build Pyramids and Statistics tool). Since the Color Balancing worked on this test mosaic, I assume that some form of Calculate Statistics can work on MrSID.
My production mosaic is much more complicated. It is a derived mosaic, with source mosaics and their MrSIDs spanning several years and created by/with different Cameras, software, people...
Do you think it could be an issue of certain versions of MrSID (e.g. lossy/lossless, different generations) or trying to color balance a derived mosaic? Or perhaps, a different kind of error being erroneously reported as an error with statistics (during the color balancing attempts)?
Thanks again,
Mike