Hi David
This isn't supported when you configure a Shortlist. Shortlist was designed for the tabs to switch between different themes for the same area, like a city, and to let the user zoom in to a particular part of that area to explore what's in that area, using the tabs to switch between the themes. It's on our list to look into providing because it does get requested here on Geonet quite a lot.
For example with what you are requesting you could have a guide to a city where the Hiking tab shows a different extent than the Restaurants tab because the hiking trails are found over a much wider area. In the short term we at least would like to make it easier to be able to customize the Shortlist to provide this behavior via code, but ideally down the road we would let you do this as a configuration in the Builder. A related enhancement is the ability to show different supporting layers for different tabs, so your Hiking tab could display line features for the trails which would be hidden on the other tabs. We don't have releases planned yet for these enhancements.
Just as a tip you could use Story Map Series now to present a set of tabs where each tab shows a different extent and set of layers, but it wouldn't have the Shortlist tile-based user interface for the places of interest.
Hope that helps.
Rupert