I need change the default behavior of the map control in (.Net app) of the mouse wheel for zoom in/out-- default is roll forward to zoom out, and I need roll forward to zoom in. In 9.3.1, I was able to change the behavior using the registry setting found in this thread
I should add that I can reverse the zoom direction in ArcMap 10.1 using the options setting, but this has no affect on zoom behavior in the Arc engine application (not that this is a viable option-- just thought there may be a new registry value that might be useful).