My map layer disappears in Layout View

[sniffysmom]

Hi.  My map layer of counties shows up well in Data view, but when I switch to Layout view, I get this:

[KimGarbade]

By the greyed out check mark next to the Colorado County Boundaries box I would say that the layer is set not the turn on at the scale you are mapping it at.  Right click the layer in your table of contents and select Properties.  Then go to the General Tab and see if it is set to turn of out beyond or in beyond a certain scale?