Just to clarify, what you want is the average distance in the N-S direction, that could be given for example by averaging the difference in latitude (in radian) between pairs of points belonging to the two lines for a given, discrete set of longitudes, and multiplying the outcome by the earth radius? I am asking because your screenshot is showing a multiple-rings buffer based on the red line, and if you would for example create a narrow buffer around the blue line and perform a zonal stat. of the distance represented by each ring using the narrow buffer as a zone, you would indeed compute a rough estimate of a distance orthogonal to the red line..
I would be interested as well to see an experienced user bringing a sound answer. There are several tricks that I could foresee as a casual GIS user, and I will explain them if needed.
Best regards,
Cedric
PS: what is the scale of your map by the way? After several interactions with ESRI, it seems to me that there is almost no way to perform geodesic computations in ArcGIS and, as there is no global equidistant projection, this is a problem for large scale distance computations. This is an open question to me indeed; I personally perform my geodesic computations with MATLAB and I would be thrilled to open another thread about this point if someone tells me that I am wrong on this PS.