Hi Brandon,
Running statistics in Po did not make any change to the mosaic, whereas the Build Overview tool keeps crashing the application at about 5% into the process.
I re-ran these tools in ArcMap too. Calculate Statistics finished OK. Build Overviews finished with some warnings, but the image looks nothing like the original:
So I did some more tests and it seems that although the mosaic displays OK in ArcMap, it still references to the original images somehow when trying to build the overviews. I can see the old path to the tiles that does not exist anymore being called during geoprocessing. Is that normal? I'm a bit baffled by this, because I always thought a mosaic stores the image physically in a blob field for any further processing. (And only unmanaged raster catalogs reference to the image by its path.) If that's true, trying to access the path that has been used for loading the tiles in the first place makes no sense to me.
I attached the geoprocessing results of the old mosaic from ArcMap in case you want to have a look...
On the other hand, when I create a new mosaic and load the tiles from another folder, run Statistics and Overview, they display OK in Pro.
Zoltan