Is there a way to ensure that an Elevation Profile, when inserted into a layout, would interact with the line the Profile is representing? For instance, if I were to click or tap on either the Profile or the line, the line or Profile might light up at that respective point?
Interactive elevation profile basics—ArcGIS Pro | Documentation
An image can be included as an element on a layout or report.
no mention of it remaining interactive on a layout
I don't believe the elevation profile remains interactive in a map layout. Can be exported as an image as Dan mentioned but then becomes static.