@SCVOSAGIS_Program Using ArcGIS Desktop (Pro or Map) with a file syncing service such as SharePoint, OneDrive. DropBox, etc may work if you are lucky or it will fail spectacularly when you least need it.
There is an option to go full cloud native - in either Azure or AWS you can host both the desktop app and file storage in the 'cloud' thereby still having your processing and data close to each other (with is always the goal). This has been a thing for almost a decade yet not spoken of often enough in my opinion.
Some Esri resellers offer this as a service where they take care of the full deployment and you only worry about your data and processes. This means you do not have to have IT skills with cloud native GIS experience in-house.
Even if you use AGOL as the main data store, there will still be the local processing, cleaning, etc requirements and the last thing you want is for users to manage data on a laptop C: drive all over the world because 'the vpn was too slow today'. AppStream and equivalents work well on most proper internet services, even airport wifi (and as no data is being transferred just the AppStream stream that you secure appropriately, things will feel much snappier than accessing data stores over a vpn) .
With user based licensing your users can fall back to a local instance of Pro if they are fully offline due to outages, etc. but you should have that covered already with your current hybrid setup.
Personally, I run big desktops with 10GBE to local servers, with multiple backup strategies. My clients don't pay me to wait for data to load, and I don't go out much 🙂
