Yes, the thing with EGDB locks inside of ArcGIS Pro, it's entirely dependent upon ArcGIS Pro to manage them. So depending upon how the developers have coded Pro to manage locks from one version to the next, will result in GP tools working one way or another. My guess is, with newer tools and functions being developed every day in ArcGIS Enterprise and rolled out in updates, you will see functions that worked perfectly, sometimes for years, then suddenly stop working. I recently experienced such an issue with a very commonly used GP Tool, which was even part of a daily automation that served my entire organization. Took me days to figure out what broke it and how to work around it. Best of luck in your journey forward!
