It would be ideal to be able to access the Maplex Labeling Engine through Python as well.
John,
The Maplex settings are available to Python via CIM access. Here is a help topic that explains what that means: https://pro.arcgis.com/en/pro-app/latest/arcpy/mapping/python-cim-access.htm
If you were to provide a couple of workflows or settings you are trying to modify, I might be able to provide a sample or two.
Jeff - arcpy.mp and Layout teams
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