One thing that I always spend time changing as I produce a map layout is the spelling of the units on the scale bar - from the American spelling "Meters" to the usual international (SI) spelling "metres". Likewise "kilometres", etc. This is currently possible in the scale bar properties dialogue, but I have to do it every time.
It would be very nice if defaults for these spellings could be configured by the user, or perhaps based on the localization settings of my machine.
(It would also save me a lot of time, and a great deal of being pedantic with other makers of maps...) :)