When creating guides on the layout, there should be an option to preset and select preset guides. This would funtion similar to setting custom scales.
These are the current guide options
With the current method, I constantly have to remove and re-add the guides as I am working, setting a new interval every time.
These are the scale options. The guide options could be similar, allowing you to select units and the fraction of unit that the user wants the guides.
If it were set up like the scale options, I could select page units and define custom guides I use frequently.