Are you experiencing slowness initially opening a project in ArcGIS Pro?
Do you have a large amount of Enterprise SDE content in your map views / layouts?
Then consider unticking the "Skip enterprise database connections" under ArcGIS Pro > Options
My suggestion to ESRI is:
Change: update the hover text or add a popup when users add a SDE databases connection to consider indexing options
Why: as above, the "skip" enterprise connections is ticked on by default, so the user needs a reminder to consider indexing SDE content should they have more of it say compared to just file geodatabase