The Trend Analysis ESDA tool has a horizontal and vertical slide bar that allows you to rotate the graph. As you move these sliders, you'll see the projected points (the green and blue points) change accordingly, and the trend lines will change to fit the new projected points. By aligning the graph at different angles, you can see how the trend changes in different directions.
When you use trend removal in the Geostatistical Wizard, these directional trends will be automatically detected using local polynomial interpolation, and it will do its best to remove them before fitting the semivariogram.
One caveat is that it is often difficult (if not impossible) to differentiate trend, autocorrelation, and anisotropy. They can all present themselves in ways that look identical.
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